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LEPU Medical
LEPU Medical
MWX205

MWX205

Investigational GalNAc-siRNA targeting PCSK9 and ANGPTL3
MWX205
MWX205
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Clinical Trials


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View onClinicalTrials.gov


Development Highlights


1.    Dual-Target Mechanism:  

A single GalNAc-siRNA designed to simultaneously silence PCSK9 and ANGPTL3, addressing complementary pathways in LDL-C and triglyceride-rich lipoprotein metabolism.

2.    First-in-Class Development:

MWX205 is the world’s first PCSK9/ANGPTL3 dual-target siRNA to enter clinical development, with a Phase 1 clinical program underway.

3.    Potential for Comprehensive Lipid Management:

Designed to address both elevated LDL-C and triglycerides, with the potential to simplify long-term lipid management by integrating two lipid-lowering mechanisms into a single therapeutic.


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