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MWX401

MWX401

Investigational AGT-targeting siRNA for primary hypertension
MWX401
MWX401
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Clinical Trials


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View onClinicalTrials.gov


Development Highlights:


1.  Upstream RAS Targeting:
Designed to silence angiotensinogen (AGT) expression, reducing the precursor available for downstream angiotensin production and modulating the renin–angiotensin system (RAS) at its source.

2.  RNAi-Based Antihypertensive Approach:
An investigational siRNA approach to blood pressure management that suppresses AGT synthesis, offering a distinct mechanism from therapies that inhibit downstream RAS enzymes or receptors.

3.  Potential for Sustained Action:
Designed for sustained AGT suppression following subcutaneous administration, with the potential to support infrequent dosing for long-term hypertension management.


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