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LEPU Medical
MWN117 Injection

MWN117 Injection

Investigational GalNAc-siRNA targeting INHBE.
MWN117 Injection
MWN117 Injection
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Clinical Trials


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View on ClinicalTrials.gov


Development Highlights


1. Targeting Liver–Adipose Signaling

An investigational siRNA designed to silence hepatic INHBE expression and reduce Activin E production, modulating liver–adipose signaling to explore a non-incretin approach to obesity treatment.

2. Potential to Improve Body Composition
Supported by human genetic evidence and preclinical findings, MWN117 is being investigated for its potential to reduce visceral fat and improve body composition.

3. Potential to Complement Incretin-Based Therapies
Preclinical findings support further investigation of MWN117 alongside GLP-1 receptor agonists, with the aim of achieving additional fat loss while preserving muscle mass.


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