DNA methylation is an epigenetic regulator of gene expression that usually results in gene silencing. Increased methylation of tumor suppressor genes could be one of the first detectable neoplastic changes associated with tumorigenesis.
Circulating tumor DNA (ctDNA) carrying cancer-specific genetic or epigenetic alterations is released into the circulation from cancer cells undergoing apoptosis or necrosis.
Analysis of specifically methylated ctDNA from patients can localize the cancer signal earlier and more accurately, helping inform next steps to diagnosis.
Applicable Groups
Inspection Process
Features
Specification
Test Kit
Method
Sample
Storage
Expiration Date
Type(s)/ Model(s)
Certificate
Lung Cancer
qPCR
DNA
-25°C to 15°C
12 months
30 tests
CE
Colorectal Cancer
qPCR
DNA
-25°C to 15°C
12 months
30 tests
CE
DNA Extraction Reagent
Magnetic Beads
Plasma
Room Temperature
12 months
30 tests
CE
FAQs of Early Cancer Diagnosis Solution
Q.
What method is mainly used for methylation detection, and what instruments and reagents are used?
A.
Based on molecular diagnosis, the product aims to assess methylation level ctDNA in blood. Required devices include nucleic acid extractor (Recommend: Automatic Nucleic Acid Extractor NA4424+PT-PCR Lepgen-96) and Diagnostic Kit for Methylated Genes of different cancers.
Q.
Can methylation testing be used at different stages of cancer? How's the effect?
A.
We have done comparison and data analysis for different cancer stage patients. Results indicate reliable sensitivity and specificity for different periods and different cancer types.
Q.
What are the reagent shipping and storage conditions?
A.
Nucleic acid extraction reagents need to be stored in room temperature; PCR reagents are required in a -25°C to -15°C condition.
Transport conditions: nucleic acid extraction reagents: dangerous goods at room temperature; PCR reagents: cold chain transport at 2 ℃-8 ℃.
Q.
Which blood sample is used for this test, whole blood or plasma?
A.
5ml plasma is required for testing.
FAQs of Early Cancer Diagnosis Solution
Q.
What method is mainly used for methylation detection, and what instruments and reagents are used?
A.
Based on molecular diagnosis, the product aims to assess methylation level ctDNA in blood. Required devices include nucleic acid extractor (Recommend: Automatic Nucleic Acid Extractor NA4424+PT-PCR Lepgen-96) and Diagnostic Kit for Methylated Genes of different cancers.
Q.
Can methylation testing be used at different stages of cancer? How's the effect?
A.
We have done comparison and data analysis for different cancer stage patients. Results indicate reliable sensitivity and specificity for different periods and different cancer types.
Q.
What are the reagent shipping and storage conditions?
A.
Nucleic acid extraction reagents need to be stored in room temperature; PCR reagents are required in a -25°C to -15°C condition.
Transport conditions: nucleic acid extraction reagents: dangerous goods at room temperature; PCR reagents: cold chain transport at 2 ℃-8 ℃.
Q.
Which blood sample is used for this test, whole blood or plasma?
A.
5ml plasma is required for testing.
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